LUNA Beauty NAD+ 500mg

Nicotinamide Adenine Dinucleotide is a critical coenzyme found in every living cell. It plays an essential role in cellular energy metabolism, acting as a key electron carrier in the electron transport chain during mitochondrial ATP production. Beyond energy, NAD+ fuels longevity enzymes like sirtuins and PARPs (poly ADP-ribose polymerases), which regulate DNA repair, inflammation, epigenetic signalling, and cellular stress responses. As we age, NAD+ levels decline sharply, impairing mitochondrial function and accelerating the breakdown of metabolic control, immune tolerance, and genomic stability. NAD+ also modulates circadian rhythm, enhances neuronal plasticity, and supports redox balance during oxidative stress. Its systemic reach is one of the widest in the longevity landscape.

Therapeutic Applications

• Support for mitochondrial ATP production and metabolic efficiency
• Activation of sirtuins and support for DNA repair enzymes
• Enhancement of cellular resilience to stress and inflammation
• Neurological support in TBI, neurodegeneration, or brain fog
• Optimisation of metabolic flexibility in aging or high-performance athletes
• Immune modulation during illness or chronic inflammation
• Regeneration in NAD-depleted states such as overtraining, sleep deprivation, alcohol use, or chronic stress

Duration Mental clarity, focus, and mitochondrial output improved within 30-90 minutes. Can be taken continuously at lower doses. Or used in pulsed, high-dose blocks during recovery phases, mitochondrial support, or post-illness rebuild.

Side Effects

• High doses may cause temporary nausea, pressure in the chest, or a “rushing” sensation
• Oral precursors are generally well tolerated, but may cause flushing or mild GI discomfort
• Prolonged high-dose use of precursors without methylation support may deplete SAMe, choline, or B12, leading to fatigue or irritability
• Rare cases of anxiety or restlessness at very high NAD levels

Use Cases

• Neurological support: NAD+ enhances mitochondrial resilience in neurons, promotes BDNF signaling, and is being studied in Alzheimer’s, Parkinson’s, TBI, and cognitive aging
• Recovery from overreaching: Supports cellular repair in athletes during high-output blocks, chronic stress, or sleep debt
• Longevity-focused protocols: Often stacked with Methylene Blue, MOTS-c, and Urolithin A for deep mitochondrial restoration and redox control
• Post-infection and long-COVID recovery: Helps restore mitochondrial function, immune tone, and neurological clarity in states of chronic depletion
• Addiction and detox: Used intravenously in addiction recovery settings to support neurochemical balance and cellular detoxification